Reversing exhaustion

Reversing T-cell Dysfunction and Exhaustion in Cancer.

In the context of chronic antigen exposure in chronic viral infections and cancer, T cells become exhausted/dysfunctional. These exhausted T cells exhibit defective proliferative capacities and cytokine production, but are not totally inert and may exert lytic functions. Importantly, exhausted T cells upregulate multiple inhibitory receptors/immune checkpoints that bind to their ligands express...

Reversing Cachexia

Muscle atrophy (cachexia) in cancer patients is a life-threatening condition for which therapeutic options are limited. Zhou et al. (2010) now identify a new target for treating cachexia, the activin type-2 receptor (ActRIIB). In several mouse models of cachexia, the authors reversed wasting of skeletal and cardiac muscle and increased life span by blocking ActRIIB with a decoy receptor.

Reversing Crc – Theory and Practice. Reversing Crc { Theory and Practice

The Cyclic Redundancy Check (CRC) was developed as a checksum algorithm for the detection of data corruption in the process of data transmission or storage. However, in some scenarios there's a CRC given which a set of data is expected to have, so the data itself has to be modi ed (at the end or at some chosen position) in a way that it computes to the given CRC checksum afterwards. We present ...

SnapShot: T Cell Exhaustion

Reversing ADP-ribosylation

The modification of serines by molecules of ADP-ribose plays an important role in signaling that the DNA in a cell has been damaged and needs to be repaired.